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Consequently, a strategy that focuses on breaking the seizureinflammationcircuit instability loop through targeted modulation of long-range neural circuits and projection pathways is essential for advancing epilepsy treatment

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"Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB -dependent transcription of Wnt-2." Neuron 50(6): 897-909

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R.MetselaarB.GreenoughM.BushA

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Figure 3: IC 50 of MRTX1133 inhibition of active KRAS-G12D in cell lysate from AsPC-1 using the KRAS In-well Lysis ELISA Kit

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